Therapeutic Potential of Shark Anti-ICOSL VNAR Domains is Exemplified in a Murine Model of Autoimmune Non-Infectious Uveitis.
Marina Kovaleva, Katherine Johnson, John Steven, Caroline J. Barelle and Andrew Porter.
Front. Immunol, 25 September 2017, Volume 8

(Paper)

Structural insights and biomedical potential of IgNAR scaffolds from sharks.
Zielonka S, Empting M, Grzeschik J, Könning D, Barelle CJ, Kolmar H.
MAbs. 2015; 7(1):15-25. doi: 10.4161/19420862.2015.989032.

(PubMed)

VNARs: An Ancient and Unique Repertoire of Molecules That Deliver Small, Soluble, Stable and High Affinity Binders of Proteins
Caroline Barelle, Andy Porter
Antibodies 2015, 4(3), 240-258; doi:10.3390/antib4030240

(Journal)

Shark variable new antigen receptor biologics – a novel technology platform for therapeutic drug development.
Kovaleva M, Ferguson L, Steven J, Porter A, Barelle C.
Expert Opin Biol Ther. 2014 Oct; 14(10):1527-39. doi: 10.1517/14712598.2014.937701. Epub 2014 Aug 4.

(PubMed)

Atypical antigen recognition mode of a shark immunoglobulin new antigen receptor (IgNAR) variable domain characterized by humanization and structural analysis.
Kovalenko OV, Olland A, Piché-Nicholas N, Godbole A, King D, Svenson K, Calabro V, Müller MR, Barelle CJ, Somers W, Gill DS, Mosyak L, Tchistiakova L.
J Biol Chem. 2013 Jun 14; 288(24):17408-19. doi: 10.1074/jbc.M112.435289. Epub 2013 Apr 30.

(PubMed)

Improving the pharmacokinetic properties of biologics by fusion to an anti-HSA shark VNAR domain.
Müller MR, Saunders K, Grace C, Jin M, Piche-Nicholas N, Steven J, O’Dwyer R, Wu L, Khetemenee L, Vugmeyster Y, Hickling TP, Tchistiakova L, Olland S, Gill D, Jensen A, Barelle CJ.
MAbs. 2012 Nov-Dec; 4(6):673-85. doi: 10.4161/mabs.22242.

(PubMed)

Generation and isolation of target-specific single-domain antibodies from shark immune repertoires.
Müller MR, O’Dwyer R, Kovaleva M, Rudkin F, Dooley H, Barelle CJ.
Methods Mol Biol. 2012; 907:177-94. doi: 10.1007/978-1-61779-974-7_9.

(PubMed)

Characterization of the immunoglobulin repertoire of the spiny dogfish (Squalus acanthias).
Smith LE, Crouch K, Cao W, Müller MR, Wu L, Steven J, Lee M, Liang M, Flajnik MF, Shih HH, Barelle CJ, Paulsen J, Gill DS, Dooley H.
Dev Comp Immunol. 2012 Apr; 36(4): 665-79. doi: 10.1016/j.dci.2011.10.007. Epub 2011 Oct 20.

(PubMed)

Shark novel antigen receptors–the next generation of biologic therapeutics?
Barelle C, Gill DS, Charlton K.
Adv Exp Med Biol. 2009; 655:49-62. doi: 10.1007/978-1-4419-1132-2_6.

(PubMed)